VGF ist ein Gen, das durch das Symbol VGF kodiert wird. Es ist auch bekannt als Neurosecretory protein VGF. VGF hat eine Masse von 67.26kDa und eine Aminosäurelänge von 615.
Wir bieten 7 antikörper gegen VGF, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity).
Entrez Zusammenfassung
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
Gewebespezifität
Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
Posttranslationale Modifikation
Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure.
Zellort
Secreted. Cytoplasmic vesicle > Secretory vesicle.
Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
