VEGFB ist ein Gen, das durch das Symbol VEGFB kodiert wird. Es ist auch bekannt als: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF. VEGFB hat eine Masse von 21.6kDa und eine Aminosäurelänge von 207.
Wir bieten 7 antikörper gegen VEGFB, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Entrez Zusammenfassung
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Gewebespezifität
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Sequenzähnlichkeiten
Belongs to the PDGF/VEGF growth factor family.
Posttranslationale Modifikation
VEGF-B186 is O-glycosylated.
Zellort
Secreted.
Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
