VAMP2 ist ein Gen, das durch das Symbol VAMP2 kodiert wird. Es ist auch bekannt als: Vesicle-associated membrane protein 2; VAMP-2; Synaptobrevin-2; SYB2. VAMP2 hat eine Masse von 12.66kDa und eine Aminosäurelänge von 116.
Wir bieten 6 antikörper gegen VAMP2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Gewebespezifität
Nervous system and skeletal muscle.
Sequenzähnlichkeiten
Belongs to the synaptobrevin family.
Posttranslationale Modifikation
Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
Zellort
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome. Cell membrane.
Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651).
