UNG ist ein Gen, das durch das Symbol UNG kodiert wird. Es ist auch bekannt als: Uracil-DNA glycosylase; UDG; DGU115. UNG hat eine Masse von 34.65kDa, eine Aminosäurelänge von 313, und ist an Immunodeficiency with hyper-IgM 5 beteiligt.
Wir bieten 11 antikörper gegen UNG, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Entrez Zusammenfassung
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
Gewebespezifität
Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
Rolle bei Krankheiten
Immunodeficiency with hyper-IgM 5: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
Sequenzähnlichkeiten
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Posttranslationale Modifikation
Isoform 1 is processed by cleavage of a transit peptide.
