UDP glucose dehydrogenase ist ein Gen, das durch das Symbol UGDH kodiert wird. Es ist auch bekannt als: UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UGDH. UDP glucose dehydrogenase hat eine Masse von 55.02kDa und eine Aminosäurelänge von 494.
Wir bieten 10 antikörper gegen UDP glucose dehydrogenase, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and Dot mit Proben abgeleitet von Human, Maus, Ratte und Rind.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
Sequenzähnlichkeiten
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
