UBF1 ist ein Gen, das durch das Symbol UBTF kodiert wird. Es ist auch bekannt als: Nucleolar transcription factor 1; Autoantigen NOR-90; Upstream-binding factor 1; UBF-1; UBTF; UBF. UBF1 hat eine Masse von 89.41kDa, eine Aminosäurelänge von 764, und ist an Neurodegeneration, childhood-onset, with brain atrophy beteiligt.
Wir bieten 8 antikörper gegen UBF1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.
Entrez Zusammenfassung
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.
Rolle bei Krankheiten
Neurodegeneration, childhood-onset, with brain atrophy: An autosomal dominant neurodegenerative disease with onset in childhood, characterized by progressive cortical atrophy, developmental delay, developmental regression, loss of motor skills and ambulation, absence of language, and intellectual disability.
Posttranslationale Modifikation
Phosphorylated and activated by PIK3CA.
Zellort
Nucleus > Nucleolus.
