TWF2 ist ein Gen, das durch das Symbol TWF2 kodiert wird. Es ist auch bekannt als: Twinfilin-2; A6-related protein; hA6RP; Protein tyrosine kinase 9-like; Twinfilin-1-like protein; PTK9L. TWF2 hat eine Masse von 39.55kDa und eine Aminosäurelänge von 349.
Wir bieten 7 antikörper gegen TWF2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
Gewebespezifität
Ubiquitously expressed (at protein level).
Sequenzähnlichkeiten
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
Posttranslationale Modifikation
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
Zellort
Cytoplasm > Cytoskeleton. Cytoplasm > Perinuclear region. Cell projection > Stereocilium.
Perinuclear and G-actin-rich cortical actin structure sublocalization.
