TSH Receptor ist ein Gen, das durch das Symbol TSHR kodiert wird. Es ist auch bekannt als: Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R; TSHR; LGR3. TSH Receptor hat eine Masse von 86.83kDa, eine Aminosäurelänge von 764, und ist an folgenden Krankheiten beteiligt: Hypothyroidism, congenital, non-goitrous, 1; Familial gestational hyperthyroidism; Hyperthyroidism, non-autoimmune.
Wir bieten 12 antikörper gegen TSH Receptor, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in thyroide cells (at protein level) (PubMed:11847099). Expressed in the thyroid (PubMed:2610690).
Rolle bei Krankheiten
Hypothyroidism, congenital, non-goitrous, 1: A non-autoimmune condition characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. It presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland.
Familial gestational hyperthyroidism: A condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy.
Hyperthyroidism, non-autoimmune: A condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Posttranslationale Modifikation
Glycosylated.
Zellort
Cell membrane. Basolateral cell membrane.
