Trypsin ist ein Gen, das durch das Symbol PRSS1 kodiert wird. Es ist auch bekannt als: Trypsin-1; Beta-Cationic trypsinogen; Serine protease 1 I; PRSS1; TRP1; TRY1; TRYP1. Trypsin hat eine Masse von 26.56kDa, eine Aminosäurelänge von 247, und ist an Pancreatitis, hereditary beteiligt.
Wir bieten 10 antikörper gegen Trypsin, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human und Rind.
Gen- und Proteininformationen
UniProt Zusammenfassung
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Entrez Zusammenfassung
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
Rolle bei Krankheiten
Pancreatitis, hereditary: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
Sequenzähnlichkeiten
Belongs to the peptidase S1 family.
Posttranslationale Modifikation
Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
Zellort
Secreted > Extracellular space.
