TrkC ist ein Gen, das durch das Symbol NTRK3 kodiert wird. Es ist auch bekannt als: NT-3 growth factor receptor; GP145-Trk-C; Neurotrophic tyrosine kinase receptor type 3 tyrosine kinase; NTRK3. TrkC hat eine Masse von 94.43kDa und eine Aminosäurelänge von 839.
Wir bieten 9 antikörper gegen TrkC, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Entrez Zusammenfassung
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Posttranslationale Modifikation
Ligand-mediated auto-phosphorylation.
