TRIM29 ist ein Gen, das durch das Symbol TRIM29 kodiert wird. Es ist auch bekannt als: Tripartite motif-containing protein 29; Ataxia telangiectasia group D-associated protein; ATDC. TRIM29 hat eine Masse von 65.84kDa und eine Aminosäurelänge von 588.
Wir bieten 8 antikörper gegen TRIM29, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
Gewebespezifität
Expressed in placenta, prostate and thymus.
Posttranslationale Modifikation
Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
Zellort
Cytoplasm. Lysosome.
Colocalizes with intermediate filaments.
