TRF1 ist ein Gen, das durch das Symbol TERF1 kodiert wird. Es ist auch bekannt als: Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TERF1; PIN2; TRBF1; TRF. TRF1 hat eine Masse von 50.25kDa und eine Aminosäurelänge von 439.
Wir bieten 12 antikörper gegen TRF1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Entrez Zusammenfassung
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.
Gewebespezifität
Highly expressed and ubiquitous. Isoform Pin2 predominates.
Posttranslationale Modifikation
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
Zellort
Nucleus. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Telomere.
Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
