Transferrin ist ein Gen, das durch das Symbol TF kodiert wird. Es ist auch bekannt als: SeroBeta-1 metal-binding globulin; Siderophilin; TF. Transferrin hat eine Masse von 77.06kDa, eine Aminosäurelänge von 698, und ist an Atransferrinemia beteiligt.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Entrez Zusammenfassung
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.
Gewebespezifität
Expressed by the liver and secreted in plasma.
Rolle bei Krankheiten
Atransferrinemia: A rare autosomal recessive disorder characterized by abnormal synthesis of transferrin leading to iron overload and microcytic hypochromic anemia.
Sequenzähnlichkeiten
Belongs to the transferrin family.
