Transferrin Receptor ist ein Gen, das durch das Symbol TFRC kodiert wird. Es ist auch bekannt als: Transferrin receptor protein 1; TR; T9; p90; TFRC. Transferrin Receptor hat eine Masse von 84.87kDa, eine Aminosäurelänge von 760, und ist an Immunodeficiency 46 beteiligt.
Wir bieten 63 antikörper gegen Transferrin Receptor, aufgewachsen in Kaninchen, Maus, Ziege, Ratte und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Frettchen.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Entrez Zusammenfassung
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified.
Rolle bei Krankheiten
Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Sequenzähnlichkeiten
Belongs to the peptidase M28 family. M28B subfamily.
Posttranslationale Modifikation
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Zellort
Cell membrane. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
