Transaldolase 1 ist ein Gen, das durch das Symbol TALDO1 kodiert wird. Es ist auch bekannt als: Transaldolase; TALDO1; TAL; TALDO; TALDOR. Transaldolase 1 hat eine Masse von 37.54kDa, eine Aminosäurelänge von 337, und ist an Transaldolase deficiency beteiligt.
Wir bieten 9 antikörper gegen Transaldolase 1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human, Maus, Ratte und S. cerevisiae.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Entrez Zusammenfassung
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.
Rolle bei Krankheiten
Transaldolase deficiency: An inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency.
Sequenzähnlichkeiten
Belongs to the transaldolase family. Type 1 subfamily.
