TNFRSF18 ist ein Gen, das durch das Symbol TNFRSF18 kodiert wird. Es ist auch bekannt als: Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; AITR; GITR. TNFRSF18 hat eine Masse von 26kDa und eine Aminosäurelänge von 241.
Wir bieten 17 antikörper gegen TNFRSF18, aufgewachsen in Kaninchen, Maus, Ratte und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and ChIP mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Entrez Zusammenfassung
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Gewebespezifität
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
