TLR8 ist ein Gen, das durch das Symbol TLR8 kodiert wird. Es ist auch bekannt als Toll-like receptor 8. TLR8 hat eine Masse von 119.83kDa und eine Aminosäurelänge von 1041.
Wir bieten 9 antikörper gegen TLR8, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Gewebespezifität
Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.
Sequenzähnlichkeiten
Belongs to the Toll-like receptor family.
Posttranslationale Modifikation
Ubiquitinated by RNF216; leading to degradation by the proteasome.
Zellort
Endosome membrane.
Endosomal localization confers distinctive proteolytic processing.
