TLE 1 ist ein Gen, das durch das Symbol TLE1 kodiert wird. Es ist auch bekannt als: Transducin-like enhancer protein 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; TLE1. TLE 1 hat eine Masse von 83.2kDa und eine Aminosäurelänge von 770.
Wir bieten 18 antikörper gegen TLE 1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ICC/IF, FC and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Gewebespezifität
In all tissues examined, mostly in brain, liver and muscle.
Sequenzähnlichkeiten
Belongs to the WD repeat Groucho/TLE family.
Posttranslationale Modifikation
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Zellort
Nucleus.
Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
