Tissue Factor ist ein Gen, das durch das Symbol F3 kodiert wird. Es ist auch bekannt als: TF; Coagulation factor III; Thromboplastin; F3. Tissue Factor hat eine Masse von 33.07kDa und eine Aminosäurelänge von 295.
Wir bieten 14 antikörper gegen Tissue Factor, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Entrez Zusammenfassung
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Gewebespezifität
Lung, placenta and pancreas.
Sequenzähnlichkeiten
Belongs to the tissue factor family.
