TIMP3 ist ein Gen, das durch das Symbol TIMP3 kodiert wird. Es ist auch bekannt als: Metalloproteinase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3. TIMP3 hat eine Masse von 24.15kDa, eine Aminosäurelänge von 211, und ist an Sorsby fundus dystrophy beteiligt.
Wir bieten 11 antikörper gegen TIMP3, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte, Rind, Hund und Pferd.
Gen- und Proteininformationen
UniProt Zusammenfassung
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Entrez Zusammenfassung
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Rolle bei Krankheiten
Sorsby fundus dystrophy: Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
Sequenzähnlichkeiten
Belongs to the protease inhibitor I35 (TIMP) family.
Zellort
Secreted > Extracellular space > Extracellular matrix.
