TIMP2 ist ein Gen, das durch das Symbol TIMP2 kodiert wird. Es ist auch bekannt als: Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2. TIMP2 hat eine Masse von 24.4kDa und eine Aminosäurelänge von 220.
Wir bieten 28 antikörper gegen TIMP2, aufgewachsen in Kaninchen, Maus und Sheep, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Kaninchen, Meerschweinchen und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Entrez Zusammenfassung
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Sequenzähnlichkeiten
Belongs to the protease inhibitor I35 (TIMP) family.
Posttranslationale Modifikation
The activity of TIMP2 is dependent on the presence of disulfide bonds.
