Thymidylate Synthase ist ein Gen, das durch das Symbol TYMS kodiert wird. Es ist auch bekannt als: TS; TYMS. Thymidylate Synthase hat eine Masse von 35.72kDa und eine Aminosäurelänge von 313.
Wir bieten 21 antikörper gegen Thymidylate Synthase, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Entrez Zusammenfassung
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.
Sequenzähnlichkeiten
Belongs to the thymidylate synthase family.
Zellort
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
