Thrombospondin 1 ist ein Gen, das durch das Symbol THBS1 kodiert wird. Es ist auch bekannt als: Thrombospondin-1; Glycoprotein G; THBS1; TSP; TSP1. Thrombospondin 1 hat eine Masse von 129.38kDa und eine Aminosäurelänge von 1170.
Wir bieten 5 antikörper gegen Thrombospondin 1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
Sequenzähnlichkeiten
Belongs to the thrombospondin family.
Zellort
Secreted. Cell surface. Secreted > Extracellular space > Extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum.
Secreted by thrombin-activated platelets and binds to the cell surface in the presence of extracellular Ca(2+) (PubMed:6777381). Incorporated into the extracellular matrix of fibroblasts (PubMed:6341993). Also detected in the endoplasmic reticulum and sarcoplasmic reticulum where it plays a role in the ER stress response (By similarity).
