TCTP ist ein Gen, das durch das Symbol TPT1 kodiert wird. Es ist auch bekannt als: Translationally-controlled tumor protein; Fortilin; Histamine-releasing factor; HRF; p23; TPT1. TCTP hat eine Masse von 19.6kDa und eine Aminosäurelänge von 172.
Wir bieten 7 antikörper gegen TCTP, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in calcium binding and microtubule stabilization.
Entrez Zusammenfassung
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
Sequenzähnlichkeiten
Belongs to the TCTP family.
