Syntaxin 1a ist ein Gen, das durch das Symbol STX1A kodiert wird. Es ist auch bekannt als: Syntaxin-1A; Neuron-specific antigen HPC-1; STX1A; STX1. Syntaxin 1a hat eine Masse von 33.02kDa und eine Aminosäurelänge von 288.
Wir bieten 8 antikörper gegen Syntaxin 1a, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE
Gewebespezifität
Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Sequenzähnlichkeiten
Belongs to the syntaxin family.
Posttranslationale Modifikation
Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1.
Zellort
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome. Cell membrane.
Colocalizes with KCNB1 at the cell membrane.
