Synaptotagmin 1 ist ein Gen, das durch das Symbol SYT1 kodiert wird. Es ist auch bekannt als: Synaptotagmin-1; Synaptotagmin I; SytI; p65; SYT1; SVP65; SYT. Synaptotagmin 1 hat eine Masse von 47.57kDa, eine Aminosäurelänge von 422, und ist an Baker-Gordon syndrome beteiligt.
Wir bieten 9 antikörper gegen Synaptotagmin 1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Entrez Zusammenfassung
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
Gewebespezifität
Expressed in melanocytes (PubMed:23999003).
Rolle bei Krankheiten
Baker-Gordon syndrome: An autosomal dominant neurodevelopmental disorder characterized by infantile hypotonia, congenital ophthalmic abnormalities, involuntary and hyperkinetic movements, stereotypic behavior, poor or absent speech, EEG abnormalities, and global developmental delay varying in severity from moderate to profound. Behavioral characteristics include sleep disturbance and episodic agitation.
Sequenzähnlichkeiten
Belongs to the synaptotagmin family.
Posttranslationale Modifikation
Glycosylated.
Zellort
Cytoplasmic vesicle > Secretory vesicle membrane. Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cytoplasmic vesicle > Secretory vesicle > Chromaffin granule membrane. Cytoplasm.
