STAT6 ist ein Gen, das durch das Symbol STAT6 kodiert wird. Es ist auch bekannt als: Signal transducer and activator of transcription 6; IL-4 Stat. STAT6 hat eine Masse von 94.14kDa und eine Aminosäurelänge von 847.
Wir bieten 25 antikörper gegen STAT6, aufgewachsen in Kaninchen, Maus und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Sequenzähnlichkeiten
Belongs to the transcription factor STAT family.
Posttranslationale Modifikation
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Zellort
Cytoplasm. Nucleus.
Translocated into the nucleus in response to phosphorylation.
