SSRP1 ist ein Gen, das durch das Symbol SSRP1 kodiert wird. Es ist auch bekannt als: FACT complex subunit Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; Facilitates chromatin transcription complex subunit Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; hT160; FACT80. SSRP1 hat eine Masse von 81.08kDa und eine Aminosäurelänge von 709.
Wir bieten 6 antikörper gegen SSRP1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
Sequenzähnlichkeiten
Belongs to the SSRP1 family.
Posttranslationale Modifikation
Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.
Zellort
Nucleus. Nucleus > Nucleolus. Chromosome.
Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
