spindlin 1 ist ein Gen, das durch das Symbol SPIN1 kodiert wird. Es ist auch bekannt als: Spindlin-1; Ovarian cancer-related protein; Spindlin1; SPIN1; OCR; SPIN. spindlin 1 hat eine Masse von 29.6kDa und eine Aminosäurelänge von 262.
Wir bieten 7 antikörper gegen spindlin 1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
Gewebespezifität
Highly expressed in ovarian cancer tissues.
Sequenzähnlichkeiten
Belongs to the SPIN/STSY family.
Posttranslationale Modifikation
Phosphorylated during oocyte meiotic maturation.
Zellort
Nucleus. Nucleus > Nucleolus.
