SnoN ist ein Gen, das durch das Symbol SKIL kodiert wird. Es ist auch bekannt als: Ski-like protein; Ski-related oncogene; Ski-related protein; SKIL; SNO. SnoN hat eine Masse von 76.98kDa und eine Aminosäurelänge von 684.
Wir bieten 6 antikörper gegen SnoN, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May have regulatory role in cell division or differentiation in response to extracellular signals.
Entrez Zusammenfassung
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Gewebespezifität
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
Sequenzähnlichkeiten
Belongs to the SKI family.
Posttranslationale Modifikation
Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
