SNAP23 ist ein Gen, das durch das Symbol SNAP23 kodiert wird. Es ist auch bekannt als: Synaptosomal-associated protein 23; SNAP-23; Vesicle-membrane fusion protein SNAP-23. SNAP23 hat eine Masse von 23.35kDa und eine Aminosäurelänge von 211.
Wir bieten 6 antikörper gegen SNAP23, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Entrez Zusammenfassung
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Gewebespezifität
Ubiquitous. Highest levels where found in placenta.
Sequenzähnlichkeiten
Belongs to the SNAP-25 family.
Zellort
Cell membrane. Cell membrane. Cell junction > Synapse > Synaptosome.
Mainly localized to the plasma membrane.
