Smoothened ist ein Gen, das durch das Symbol SMO kodiert wird. Es ist auch bekannt als: Smoothened homolog; SMO; Protein Gx; SMOH. Smoothened hat eine Masse von 86.4kDa, eine Aminosäurelänge von 787, und ist an Curry-Jones syndrome beteiligt.
Wir bieten 6 antikörper gegen Smoothened, aufgewachsen in Kaninchen, welche geeignet sind für WB, ELISA and Dot mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
Rolle bei Krankheiten
Curry-Jones syndrome: A multisystem disorder characterized by patchy skin lesions, polysyndactyly, diverse cerebral malformations, unicoronal craniosynostosis, iris colobomas, microphthalmia, and intestinal malrotation with myofibromas or hamartomas.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor Fz/Smo family.
Zellort
Membrane. Cell projection > Cilium.
