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Anti-SMC1 Antikörper

8 Products

SMC1 ist ein Gen, das durch das Symbol SMC1A kodiert wird. Es ist auch bekannt als: Structural maintenance of chromosomes protein 1A; SMC protein 1A; Sb1.8A; DXS423E; KIAA0178; SB1.8L1. SMC1 hat eine Masse von 143.23kDa, eine Aminosäurelänge von 1233, und ist an Cornelia de Lange syndrome 2 beteiligt.

Wir bieten 8 antikörper gegen SMC1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.

Gen- und Proteininformationen

UniProt Zusammenfassung
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Entrez Zusammenfassung
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001
Rolle bei Krankheiten
Cornelia de Lange syndrome 2: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies.
Sequenzähnlichkeiten
Belongs to the SMC family. SMC1 subfamily.
Posttranslationale Modifikation
Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.
Zellort
Nucleus. Chromosome. Chromosome > Centromere > Kinetochore.

Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.
SMC1B antibody from Signalway Antibody (22261) - Antibodies.com
(3)
Western blot - SMC1 (Phospho-Ser966) Polyclonal Antibody from Signalway Antibody (12305) - Antibodies.com
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Anti-SMC 1 (phospho-S957) Antibody from Bioworld Technology (BS4174) - Antibodies.com
Western blot - SMC1 (Ab-957) Antibody from Signalway Antibody (21190) - Antibodies.com
(2)
Anti-SMC 1 (S951) Antibody from Bioworld Technology (BS1326) - Antibodies.com
Western blot - SMC1 (Phospho-Ser957) Antibody from Signalway Antibody (11198) - Antibodies.com
(2)
Anti-SMC 1 (phospho-S957) Antibody from Bioworld Technology (BS6416) - Antibodies.com

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