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Anti-Smad4 Antikörper

49 Products

Smad4 ist ein Gen, das durch das Symbol SMAD4 kodiert wird. Es ist auch bekannt als: Mothers against decapentaplegic homolog 4; MAD homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; DPC4; MADH4. Smad4 hat eine Masse von 60.44kDa, eine Aminosäurelänge von 552, und ist an folgenden Krankheiten beteiligt: Pancreatic cancer; Juvenile polyposis syndrome; Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome; Colorectal cancer; Myhre syndrome.

Wir bieten 49 antikörper gegen Smad4, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP, Dot and ChIP mit Proben abgeleitet von Human, Maus und Ratte.

Gen- und Proteininformationen

UniProt Zusammenfassung
In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Entrez Zusammenfassung
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Rolle bei Krankheiten
Pancreatic cancer: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

Juvenile polyposis syndrome: Autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers.

Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome: JP/HHT syndrome phenotype consists of the coexistence of juvenile polyposis (JIP) and hereditary hemorrhagic telangiectasia (HHT) [MIM:187300] in a single individual. JIP and HHT are autosomal dominant disorders with distinct and non-overlapping clinical features. The former, an inherited gastrointestinal malignancy predisposition, is caused by mutations in SMAD4 or BMPR1A, and the latter is a vascular malformation disorder caused by mutations in ENG or ACVRL1. All four genes encode proteins involved in the transforming-growth-factor-signaling pathway. Although there are reports of patients and families with phenotypes of both disorders combined, the genetic etiology of this association is unknown.

Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

Myhre syndrome: A syndrome characterized by pre- and postnatal growth deficiency, mental retardation, generalized muscle hypertrophy and striking muscular build, decreased joint mobility, cryptorchidism, and unusual facies. Dysmorphic facial features include microcephaly, midface hypoplasia, prognathism, and blepharophimosis. Typical skeletal anomalies are short stature, square body shape, broad ribs, iliac hypoplasia, brachydactyly, flattened vertebrae, and thickened calvaria. Other features, such as congenital heart disease, may also occur.
Sequenzähnlichkeiten
Belongs to the dwarfin/SMAD family.
Posttranslationale Modifikation
Phosphorylated by PDPK1.
Zellort
Cytoplasm. Nucleus.

Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
Cut&Tag - Anti-Smad4 Antibody [ARC5009-06] (A308139) - Antibodies.com
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Western Blot - Anti-Smad4 Antibody (C10983) - Antibodies.com
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Western Blot - Anti-Smad4 Antibody (R12-3546) - Antibodies.com
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Immunohistochemistry - Anti-SMAD4 Antibody [SMAD/6309R] (A278027) - Antibodies.com
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Immunohistochemistry - Anti-SMAD4 Antibody [SMAD/6309R] - BSA and Azide free (A278615) - Antibodies.com
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Immunohistochemistry - Anti-Smad4 Antibody [RM277] (A121393) - Antibodies.com
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Western Blot - Anti-Smad4 Antibody (A305558) - Antibodies.com
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Western Blot - Anti-Smad4 Antibody (A92998) - Antibodies.com
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Western Blot - Anti-Smad4 Antibody (A304891) - Antibodies.com
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Immunohistochemistry - Anti-SMAD4 Antibody [SMAD4/2440] - BSA and Azide free (A252451) - Antibodies.com
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SDS-PAGE - Anti-SMAD4 Antibody [SMAD4/2524] (A249272) - Antibodies.com
Immunohistochemistry - Anti-SMAD4 Antibody [SMAD4/2440] (A249271) - Antibodies.com
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SDS-PAGE - Anti-SMAD4 Antibody [SMAD4/2524] - BSA and Azide free (A252452) - Antibodies.com
Immunohistochemistry - Anti-SMAD4 Antibody [SPM448] - BSA and Azide free (A252451) - Antibodies.com
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Immunohistochemistry - Anti-SMAD4 Antibody [SPM448] (A249271) - Antibodies.com
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Anti-Smad4 (L43) Antibody from Bioworld Technology (BS2050) - Antibodies.com
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Western blot - SMAD4 Antibody from Signalway Antibody (32954) - Antibodies.com
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Anti-Smad4 Antibody from Bioworld Technology (BS7225) - Antibodies.com
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Western blot - Smad4 (Phospho-Thr276) Antibody from Signalway Antibody (12637) - Antibodies.com
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Anti-Smad4 Antibody from FabGennix (SMAD4-401AP) - Antibodies.com
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Western blot - Smad4 Antibody from Signalway Antibody (33868) - Antibodies.com
SMAD4 Antibody from Signalway Antibody (31017) - Antibodies.com
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