Siglec 7 ist ein Gen, das durch das Symbol SIGLEC7 kodiert wird. Es ist auch bekannt als: Sialic acid-binding Ig-like lectin 7; Siglec-7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; SIGLEC7; AIRM1. Siglec 7 hat eine Masse von 51.14kDa und eine Aminosäurelänge von 467.
Wir bieten 14 antikörper gegen Siglec 7, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, FC and IP mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Gewebespezifität
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Posttranslationale Modifikation
Tyrosine phosphorylated.
