SIAH Interacting Protein ist ein Gen, das durch das Symbol CACYBP kodiert wird. Es ist auch bekannt als: Calcyclin-binding protein; CacyBP; S100A6-binding protein; Siah-interacting protein; CACYBP; S100A6BP; SIP. SIAH Interacting Protein hat eine Masse von 26.21kDa und eine Aminosäurelänge von 228.
Wir bieten 6 antikörper gegen SIAH Interacting Protein, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Entrez Zusammenfassung
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Posttranslationale Modifikation
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
Zellort
Nucleus. Cytoplasm.
Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
