SH2D1B ist ein Gen, das durch das Symbol SH2D1B kodiert wird. Es ist auch bekannt als: SH2 domain-containing protein 1B; EWS/FLI1-activated transcript 2; EAT-2; EAT2. SH2D1B hat eine Masse von 15.3kDa und eine Aminosäurelänge von 132.
Wir bieten 2 antikörper gegen SH2D1B, aufgewachsen in Kaninchen, welche geeignet sind für IHC and ELISA mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Entrez Zusammenfassung
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001
