SFRP4 ist ein Gen, das durch das Symbol SFRP4 kodiert wird. Es ist auch bekannt als: Secreted frizzled-related protein 4; sFRP-4; Frizzled protein, human endometrium; FrpHE; FRPHE. SFRP4 hat eine Masse von 39.83kDa, eine Aminosäurelänge von 346, und ist an Pyle disease beteiligt.
Wir bieten 6 antikörper gegen SFRP4, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Entrez Zusammenfassung
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Gewebespezifität
Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
Rolle bei Krankheiten
Pyle disease: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
Sequenzähnlichkeiten
Belongs to the secreted frizzled-related protein (sFRP) family.
Zellort
Secreted.
Cytoplasmic in ovarian tumor cells.
