Serotonin transporter ist ein Gen, das durch das Symbol SLC6A4 kodiert wird. Es ist auch bekannt als: Sodium-dependent SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4; SLC6A4; HTT. Serotonin transporter hat eine Masse von 70.33kDa und eine Aminosäurelänge von 630.
Wir bieten 7 antikörper gegen Serotonin transporter, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte und Rind.
Gen- und Proteininformationen
UniProt Zusammenfassung
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Entrez Zusammenfassung
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Gewebespezifität
Expressed in platelets (at protein level).
Sequenzähnlichkeiten
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
Posttranslationale Modifikation
Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.
Zellort
Cell membrane. Endomembrane system. Endosome membrane. Cell junction > Synapse. Cell junction > Focal adhesion.
Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).
