SEPT6 ist ein Gen, das durch das Symbol SEPTIN6 kodiert wird. Es ist auch bekannt als: Septin-6; SEPTIN6; KIAA0128; SEP2. SEPT6 hat eine Masse von 49.72kDa und eine Aminosäurelänge von 434.
Wir bieten 7 antikörper gegen SEPT6, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
Entrez Zusammenfassung
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
Gewebespezifität
Widely expressed.
Sequenzähnlichkeiten
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Zellort
Cytoplasm. Cytoplasm > Cytoskeleton > Spindle. Chromosome > Centromere > Kinetochore. Cleavage furrow. Midbody. Cell projection > Cilium > Flagellum.
In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830).
