Separase ist ein Gen, das durch das Symbol ESPL1 kodiert wird. Es ist auch bekannt als: Separin; Caspase-like protein ESPL1; Extra spindle poles-like 1 protein; ESPL1; ESP1; KIAA0165. Separase hat eine Masse von 233.18kDa und eine Aminosäurelänge von 2120.
Wir bieten 8 antikörper gegen Separase, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Entrez Zusammenfassung
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009
Posttranslationale Modifikation
Autocleaves. This function, which is not essential for its protease activity, is unknown.
Zellort
Cytoplasm. Nucleus.
