S100 calcium binding protein A14 ist ein Gen, das durch das Symbol S100A14 kodiert wird. Es ist auch bekannt als: Protein S100-A14; S100 calcium-binding protein A14; S114; S100A14; S100A15. S100 calcium binding protein A14 hat eine Masse von 11.66kDa und eine Aminosäurelänge von 104.
Wir bieten 10 antikörper gegen S100 calcium binding protein A14, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
Entrez Zusammenfassung
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828).
Gewebespezifität
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
Sequenzähnlichkeiten
Belongs to the S-100 family.
