RPL10 ist ein Gen, das durch das Symbol RPL10 kodiert wird. Es ist auch bekannt als: 60S ribosomal protein L10; Laminin receptor homolog; Large ribosomal subunit protein uL16; Protein QM; Ribosomal protein L10; Tumor suppressor QM; DXS648E; QM. RPL10 hat eine Masse von 24.6kDa, eine Aminosäurelänge von 214, und ist an folgenden Krankheiten beteiligt: Autism, X-linked 5; Mental retardation, X-linked, syndromic, 35.
Wir bieten 6 antikörper gegen RPL10, aufgewachsen in Kaninchen, welche geeignet sind für WB and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).
Entrez Zusammenfassung
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants.
Rolle bei Krankheiten
Autism, X-linked 5: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Mental retardation, X-linked, syndromic, 35: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Sequenzähnlichkeiten
Belongs to the universal ribosomal protein uL16 family.
Posttranslationale Modifikation
Citrullinated by PADI4.
