ROR1 ist ein Gen, das durch das Symbol ROR1 kodiert wird. Es ist auch bekannt als: Inactive tyrosine-protein kinase transmembrane receptor Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1. ROR1 hat eine Masse von 104.28kDa, eine Aminosäurelänge von 937, und ist an Deafness, autosomal recessive, 108 beteiligt.
Wir bieten 16 antikörper gegen ROR1, aufgewachsen in Kaninchen, Ziege und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
Entrez Zusammenfassung
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Rolle bei Krankheiten
Deafness, autosomal recessive, 108: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Zellort
Membrane. Cell projection > Axon.
