RHOD ist ein Gen, das durch das Symbol RHOD kodiert wird. Es ist auch bekannt als: Rho-related GTP-binding protein Rho-related protein HP1; RhoHP1; ARHD. RHOD hat eine Masse von 23.41kDa und eine Aminosäurelänge von 210.
Wir bieten 7 antikörper gegen RHOD, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Entrez Zusammenfassung
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Rho family.
Zellort
Cell membrane. Early endosome.
Colocalizes with RAB5 to early endosomes (By similarity).
