RHOB ist ein Gen, das durch das Symbol RHOB kodiert wird. Es ist auch bekannt als: Rho-related GTP-binding protein Rho cDNA clone 6; h6; ARH6; ARHB. RHOB hat eine Masse von 22.12kDa und eine Aminosäurelänge von 196.
Wir bieten 6 antikörper gegen RHOB, aufgewachsen in Kaninchen, welche geeignet sind für WB and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Rho family.
Posttranslationale Modifikation
Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
Zellort
Late endosome membrane. Cell membrane. Nucleus. Cleavage furrow.
Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
