Retinoic Acid Receptor gamma ist ein Gen, das durch das Symbol RARG kodiert wird. Es ist auch bekannt als: RAR-gamma; Nuclear receptor subfamily 1 group B member 3; RARG; NR1B3. Retinoic Acid Receptor gamma hat eine Masse von 50.34kDa und eine Aminosäurelänge von 454.
Wir bieten 6 antikörper gegen Retinoic Acid Receptor gamma, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
Entrez Zusammenfassung
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in aortic endothelial cells (at protein level).
Sequenzähnlichkeiten
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Zellort
Nucleus. Cytoplasm.
