Renalase ist ein Gen, das durch das Symbol RNLS kodiert wird. Es ist auch bekannt als: Monoamine oxidase-C; MAO-C; RNLS; C10orf59. Renalase hat eine Masse von 37.85kDa und eine Aminosäurelänge von 342.
Wir bieten 6 antikörper gegen Renalase, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Entrez Zusammenfassung
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005
Gewebespezifität
Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
Sequenzähnlichkeiten
Belongs to the renalase family.
