RALB ist ein Gen, das durch das Symbol RALB kodiert wird. Es ist auch bekannt als Ras-related protein Ral-B. RALB hat eine Masse von 23.41kDa und eine Aminosäurelänge von 206.
Wir bieten 9 antikörper gegen RALB, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte, Affe und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
Entrez Zusammenfassung
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.
Sequenzähnlichkeiten
Belongs to the small GTPase superfamily. Ras family.
Posttranslationale Modifikation
Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
Zellort
Cell membrane. Midbody.
During late cytokinesis, enriched at the midbody.
