RAD52 ist ein Gen, das durch das Symbol RAD52 kodiert wird. Es ist auch bekannt als DNA repair protein RAD52 homolog. RAD52 hat eine Masse von 46.17kDa und eine Aminosäurelänge von 418.
Wir bieten 9 antikörper gegen RAD52, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte und Hamster.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Entrez Zusammenfassung
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Sequenzähnlichkeiten
Belongs to the RAD52 family.
Posttranslationale Modifikation
Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
